Squalene [PhytoSquene®]
NF, EP, Injectable Grade (US-DMF)
CAS #:
111-02-4
Molecular Formula:
C30H50
Synonym:
(all-E)-2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexaene
Molecular Weight:
410.7 g/mol
Overview
Squalene, is an organic compound that be found occurring naturally in shark liver oil and certain plants. It is a hydrocarbon that all plants and animals produce in varying quantities. Mostly used in cosmetics as a natural skin moisturizer, it has recently been used as an immunologic adjuvant in certain vaccines. It is a natural 30-carbon isoprenoid compound and intermediate metabolite in the synthesis of cholesterol. It is not susceptible to lipid peroxidation and provides skin protection. It is ubiquitously distributed in human tissues where it is transported in serum generally in association with very low-density lipoproteins. Squalene is investigated as an adjunctive cancer therapy.
| Characters | Unit | Specification |
|---|---|---|
| Identity | IR, GC | |
| Appearance | Clear, colorless, odorless liquid | |
| APHA | < 20 | |
| Assay (glpc) | ||
| Squalene | % | > 97 (by area) |
| Total Squalenes | % | > 98 (by w/w) |
| Saponification value | mg/g | ≤ 5 |
| Acid value | ≤ 0.5 mg KOH/Kg | |
| Peroxide value | meq/Kg | ≤ 5 |
| Iodine value | g | 360 – 380 g/100 g |
| Water (K-F) | % | < 0.1 |
| RI, ηD20 ºC | 1.492 - 1.498 | |
| d25 ºC | g/mL | 0.858 |
| Heavy metals | ppm | < 10 |
| Residual Solvents | EP 01/2008: 50400 (CPMP/ICH/238)/95 | |
| Pesticides Residue | USP/EP | |
| Dioxin and PCBs | pg/g | < 6153 |
| Microbiological Specification | ||
| Standard Plate Content | CFU/ml | ≤ 50 |
| Mold and Yeast | CFU/ml | ≤ 50 |
Shelf Life/Retest Date: The minimal shelf-life of Squalene, CAS 111-02-4 is 2 years when stored under recommended conditions.
Storage/Shipping Conditions:
- PhytoSquene® is light- and air-sensitive and should be handled accordingly.
- Containment under nitrogen and at or below 8°C is recommended.
Pack Sizes: 5 Kg
