Guanidine Hydrochloride

Pharma Grade

CAS #:

50-01-1

Molecular Formula:

CH5N3•HCl

Synonym:

Carbamidine Hydrochloride, Iminourea Hydrochloride, Aminomethanamidine Hydrochloride

Molecular Weight:

95.53 g/mol

Overview

Guanidine Hydrochloride is a strong protein denaturant that functions as a chaotropic agent. As a denaturant, it acts to unfold proteins and turn them into their original polypeptide chains. As a chaotropic agent, it breaks down the structure of proteins. Guanidine Hydrochloride is commonly used in the purification of RNA by dissociating the RNA into its nucleic acids and protein forms. At higher concentrations, Guanidine Hydrochloride decreases enzyme activity. It is also used to increase the solubility of hydrophobic molecules.

Characters Unit Specification
Absorbance:
260 nm a.u 0.0300 a.u. maximum
275 nm a.u 0.0300 a.u. maximum
230 nm a.u 0.2000 a.u. maximum
Appearance and Color White / Crystals
Assay % 99.5% minimum
Enzymes:
DNase None Detected
Protease None Detected
RNase None Detected
Identification (IR) Passes Test
Insoluble Matter % 0.15% maximum
Loss on Drying % 0.5% maximum
Melting Range oC 184-188ºC
Nitrate % 0.01% maximum
pH (6M) 4.5-6.0
Residue on Ignition % 0.05% maximum
Solubility (6M) Passes Test
Sulfate % 0.01% maximum
Trace Metals:
Arsenic (As) ppm 5 ppm maximum
Copper (Cu) ppm 5 ppm maximum
Iron (Fe) ppm 5 ppm maximum
Lead (Pb) ppm 5 ppm maximum

Shelf Life/Retest Date: The recommended retest period for GuanidineHydrochloride, CAS number – 50-01-1 is 2 years from the date of manufacture.

Storage/Shipping Conditions:

  • Ship and store in an ambient temperature.
  • Keep containers tightly closed.

Pack Sizes:1 Kg

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